DIABETIC RECIPE FOR A HEALTHY LIVING
Eating delicious and sumptuous food, is what each one of us craves for! After experiencing some long and tiring working hours in the office; eating well at night, seems to be life’s greatest pleasure. In this regard, having being affected with diabetes shouldn’t stop anyone from that bliss. Although, it is quite reasonable that people with chronic diabetes have quite different nutritional needs; due to which, many times, diabetic recipes can be acknowledged to be bland and tasteless. However, today, different healthy ingredients can be obtained from different parts of the world; and hence with a smart planning of your meal to allow you to manage your diabetes with the same taste and nutritional requirement.
The write up may brief our readers about few food tips to explore with better understanding of diabetes and body’s nutritional requirement.
Better understanding of Carb Requirement
Knowing about, how much carbohydrates are needed and what are the different kinds that are required; would be your first step towards, planning your diabetic recipes. In this regard, it is interesting to understand that there are about three different kinds of carbohydrates in the food, such as starches, sugars and fibers. Starchy food may include vegetables like peas, corn, lime beans, potato beans, etc. Whole grains such as oats, barley and rice can as well be categorized under starch. Although, it is important to understand that grains can be divided into whole grain, containing all the three germ layers and with all the necessary nutrients it has to offer; whereas refined grain is mainly connected with middle endosperm layer, which doesn’t contain any vitamins and nutrients, except for the starchy material.
Sugars, are classified as direct sugar, obtained from sugar cane, nectar, confectionaries, and other raw sources as well as indirect sugar that is being obtained from milk, fruits, etc. Fibre is the plant source and is required for healthy digestive system; it can contribute your nutritional requirement by making you feel full and satisfied.
Thus, it would be wise to optimize your carbohydrate requirement by opting for the most nutrient dense choices, with smaller portion size. For that matter, you need to avoid sugary drinks, including soda, sweet tea, fruit punch etc. Whole fruit should be preferred instead of juice. Sweet potatoes can be better alternative for white potato and whole grain oat meals, brown rice and/or barley should always be welcome.
More indulgence towards diabetic super foods
Thus, your healthy diabetic recipes should contain diabetic super food as listed below with a known low glycemic index and key nutrients such as, calcium, potassium, fibre, magnesium as well as vitamins mainly A, C and E. These super foods can be:
Conventional treatment pattern for diabetes is having higher emphasize on inflammatory drugs and good nutritional supplements; however, they lack effective management of the said disease, along with some additional challenges of preventing their damaging effects. On the contrary, recently launched stem cells therapy can be considered as the better alternative to effectively reduce disease progression and restore lost cellular function.
The write up may brief our readers about few food tips to explore with better understanding of diabetes and body’s nutritional requirement.
Better understanding of Carb Requirement
Knowing about, how much carbohydrates are needed and what are the different kinds that are required; would be your first step towards, planning your diabetic recipes. In this regard, it is interesting to understand that there are about three different kinds of carbohydrates in the food, such as starches, sugars and fibers. Starchy food may include vegetables like peas, corn, lime beans, potato beans, etc. Whole grains such as oats, barley and rice can as well be categorized under starch. Although, it is important to understand that grains can be divided into whole grain, containing all the three germ layers and with all the necessary nutrients it has to offer; whereas refined grain is mainly connected with middle endosperm layer, which doesn’t contain any vitamins and nutrients, except for the starchy material.
Sugars, are classified as direct sugar, obtained from sugar cane, nectar, confectionaries, and other raw sources as well as indirect sugar that is being obtained from milk, fruits, etc. Fibre is the plant source and is required for healthy digestive system; it can contribute your nutritional requirement by making you feel full and satisfied.
Thus, it would be wise to optimize your carbohydrate requirement by opting for the most nutrient dense choices, with smaller portion size. For that matter, you need to avoid sugary drinks, including soda, sweet tea, fruit punch etc. Whole fruit should be preferred instead of juice. Sweet potatoes can be better alternative for white potato and whole grain oat meals, brown rice and/or barley should always be welcome.
More indulgence towards diabetic super foods
Thus, your healthy diabetic recipes should contain diabetic super food as listed below with a known low glycemic index and key nutrients such as, calcium, potassium, fibre, magnesium as well as vitamins mainly A, C and E. These super foods can be:
- Beans
- Dark green leafy vegetables
- Citrus varieties
- Sweet Potatoes
- Berries and tomatoes
- Fish with high content of omega-3-fatty acids
- Whole grains, nuts as well as fat free milk and yogurt
Conventional treatment pattern for diabetes is having higher emphasize on inflammatory drugs and good nutritional supplements; however, they lack effective management of the said disease, along with some additional challenges of preventing their damaging effects. On the contrary, recently launched stem cells therapy can be considered as the better alternative to effectively reduce disease progression and restore lost cellular function.
INPUTS ON GLOBAL HEALTHCARE POLICIES
The Obamacare, an important health reform proposed in the era of Mr. Obama is being battling for its survival, against recent proposals offered through Mr. Trump Congress. In that sense, the new proposals have been strategized in order to modify the same; with the inclusion of benefits that are legally required, and dropping out others that are essentially not mandatory. While the US government intends to fit all types of necessary health care’s into fixed fiscal envelope, there are rather some hard decisions to be proposed; to offer any subsidies without preoptimized standards.
In this regard, many experts in the field have argued against ever increasing global healthcare data base; established on the basis of one-size-fits-all cost-effective healthcare decisions, en-routing towards universal health coverage; alternatively, they proposed evidence-informed deliberative process, acknowledging the complex political issues, such as what kind of medical procedures, medicines, devices, diagnostics should be covered? And up to what extent, it should be covered etc. Thus, the ever-evolving solutions to these core health issues should determine the success of universal health coverage.
In line with these possible assumptions various countries, such as England, Wales, Canada, Republic of Korea, etc. have come up with the establishment of national institutions, that are solely responsible for defining and shaping up of priorities for general healthcare expenditures, based upon the evidences and developmental process. These organizations, generally being identified as National Technological Assessments Centers; prioritizing and supporting novel, innovative technologies to encompass healthcare policies and their improved reachability through cost-effective platforms. In addition to which, a more systematic approach has been evolved very recently through World Health Organization and Disease Control and Prevention to support global evidences of affordable health interventions. Thus, through this current global theme, incorporated via Universal Health Coverage, it would be quite possible to routinely implement, latest technological innovations that are proving to be; cost-effective, feasible as well as therapeutically beneficial.
Accordingly, with rapid urbanization and growth in the economy of various countries; there have been notably increased evidences of growing disease burden; assigning rising demands for quality healthcare facilities, to be incorporated in national health insurance schemes. However, without an optimized priority setting techniques, healthcare benefits in more than 115 countries are not available to the common population, due to constraints in decision making and overall budgetary issues.
Thus, although cost effective analysis is important to improve health outcome of the country; a thoughtful approach, in structuring the health benefits through virtual, feasible, ethical and sustainable platform is truly essential.
Hence, with the commitment and financial contribution towards the Universal Health Coverage; it would be possible to explore global partners, in order to offer better context-sensitive evidences for effective decisions for supporting technical, institutional and information healthcare capacity.
In this regard, many experts in the field have argued against ever increasing global healthcare data base; established on the basis of one-size-fits-all cost-effective healthcare decisions, en-routing towards universal health coverage; alternatively, they proposed evidence-informed deliberative process, acknowledging the complex political issues, such as what kind of medical procedures, medicines, devices, diagnostics should be covered? And up to what extent, it should be covered etc. Thus, the ever-evolving solutions to these core health issues should determine the success of universal health coverage.
In line with these possible assumptions various countries, such as England, Wales, Canada, Republic of Korea, etc. have come up with the establishment of national institutions, that are solely responsible for defining and shaping up of priorities for general healthcare expenditures, based upon the evidences and developmental process. These organizations, generally being identified as National Technological Assessments Centers; prioritizing and supporting novel, innovative technologies to encompass healthcare policies and their improved reachability through cost-effective platforms. In addition to which, a more systematic approach has been evolved very recently through World Health Organization and Disease Control and Prevention to support global evidences of affordable health interventions. Thus, through this current global theme, incorporated via Universal Health Coverage, it would be quite possible to routinely implement, latest technological innovations that are proving to be; cost-effective, feasible as well as therapeutically beneficial.
Accordingly, with rapid urbanization and growth in the economy of various countries; there have been notably increased evidences of growing disease burden; assigning rising demands for quality healthcare facilities, to be incorporated in national health insurance schemes. However, without an optimized priority setting techniques, healthcare benefits in more than 115 countries are not available to the common population, due to constraints in decision making and overall budgetary issues.
Thus, although cost effective analysis is important to improve health outcome of the country; a thoughtful approach, in structuring the health benefits through virtual, feasible, ethical and sustainable platform is truly essential.
Hence, with the commitment and financial contribution towards the Universal Health Coverage; it would be possible to explore global partners, in order to offer better context-sensitive evidences for effective decisions for supporting technical, institutional and information healthcare capacity.
AUTIMISM: TRAILBLAZING A BRIGHT FUTURE
With the recent drift in its prevalence, society has moved further to treat autism in a positive perception. Being rhyming with the word optimism, Autimism is an initiative that has been taken to propose positive attitude towards the neurodegenerative disorder; thus, shifting the paradigm from awareness towards its acceptance, from negative stereotypes towards the better understanding of the psychology, from “how do we do it?” towards “Ohh, we have to do it!” attitude.
One of the most challenging tasks, many parents must have come across would be their employment, as a matter of fact, traditional employment would be quite difficult and meaningless for them. On the contrary, self-employment can be quite meaningful and sustainable that may emphasize on the “NOW” part, as opposed to “NOT NOW”. It has been a common observation that people with developmental disabilities mostly live in “NOW” world! For example, when they are taught something, which cannot be implemented immediately; then they drastically, tend to lose their interest and learning objectives. On the other hand, self-employment and self-engagement can motivate the person to be independent and financially literate; to achieve the said objectives, he/she will be more focused on improving their communication skills, their social networking, etc. Thus, this in turn allows them to conquer their soft spots. Moreover, it is not necessary to be of that age limit to be employed, as in case of the traditional jobs; in fact, these self-employment modules can be your transition time to learn and develop important life skills. Many parents are doubtful, whether their autistic children with developmental disorders, will understand the real meaning of self-employment and also would be interested in it; however, in reality there are many successful people with autism, like Einstein, who created and established a respectable position in a job of their own choice. In the current era, as well, there are many renowned people like Tathi Piancastelli, a young Brazilian actress and model with Down Syndrome and Shawn Smith, a Canadian businessman and a founder of “Don’t Dis-My-Ability”; personifying the level of innovation and technology towards the business table. Accordingly, there are many reputed organization, operational throughout the globe like SAP and Palisades Hudson’s, which have shared various practical as well as constructive ways for these budding entrepreneurs with disabilities. These organizations are even organizing events to share number of ways in order to fund these innovative business ventures, through crowd funding. Thus, hope and never give up attitude; can help in reshaping the lives of many people, who have been struggling with their difficult developmental disorders. Although, conventional medicine does not have anything to offer to these people, except for some of the rehabilitation techniques, steroidal medicines and frustration; modern regenerative medicine has offered remarkable improvement in behavioral as well as psychosocial attributes of people with ADHD. Stem cells therapy has been proven as a new promising medicinal innovation, which can solve the intriguing cellular puzzles to towards the successful restoration of functionalities of brain. Advancells |
ADIPOSE AND BONE MARROW DERIVED STEM CELLS: THE MEDICAL MASTER KEYS! |
Stem cells and their therapeutic applications have offered tremendous promise to cure a vast arena of degenerative diseases that have been left orphan, through conventional medications. Time and again, their potential, feasibility and safety for therapeutic application has been tested and confirmed, through number of clinical studies, which have been conducted worldwide. Although, a niche concept of stem cells therapy, has been subjected to lot of confusion, ethical debate and controversy in the recent years; scientists and the medical fraternity are struggling hard on several key issues, the more emphasize is on bringing these therapies from research bench to clinical bedside, by decoding their exact mechanism of action and fixing up the better stem cells sources, without compromising patient’s safety as well as treatment efficacy.
Although, the process of turning scientific miracles into safe and effective clinical treatments is very lengthy and multi-step; it deserves lot of appreciation, as it is designed in a way to minimize harm to patient’s body and maximize its effectiveness. Accordingly, each discovery, has to go through stringent quality checks, from petri plates to animals; before it is being actually implemented on humans. Moreover, meticulous analysis of accuracy, precision as well as peer reviews is being done; to come up with clinical conclusions. In this regard, enough data and statistical values are in place to confirm that stem cells are the real heroes; who can be trusted to treat myriad of degenerative ailments, that are being currently faced by the world!
Out of different types of stem cells sources, that have been explored so far; stem cells isolated from patient’s own body sources, like bone marrow as well as adipose tissues, have gained maximum endorsements. In this regard, several advantages have been listed out, over other types of stem cells sources.
Although, the process of turning scientific miracles into safe and effective clinical treatments is very lengthy and multi-step; it deserves lot of appreciation, as it is designed in a way to minimize harm to patient’s body and maximize its effectiveness. Accordingly, each discovery, has to go through stringent quality checks, from petri plates to animals; before it is being actually implemented on humans. Moreover, meticulous analysis of accuracy, precision as well as peer reviews is being done; to come up with clinical conclusions. In this regard, enough data and statistical values are in place to confirm that stem cells are the real heroes; who can be trusted to treat myriad of degenerative ailments, that are being currently faced by the world!
Out of different types of stem cells sources, that have been explored so far; stem cells isolated from patient’s own body sources, like bone marrow as well as adipose tissues, have gained maximum endorsements. In this regard, several advantages have been listed out, over other types of stem cells sources.
- The primary one is that patient, who serves as his/her own host for receiving stem cells, there is no risk of incompatibility or any kind of rejection by the body.
- Immunosuppression doses are really not needed, for accepting patients own body cells, avoiding many of the most reported complications, like opportunistic infections, rejection, etc.
- Since, autologous stem cells know patient body in a better way; it would not be a much hassle for these stem cells, to reach at the targeted site, for faster recovery.
- Stem cells sources, like adipose tissue and bone marrow are abundant and underutilized; hence obtaining them for stem cells extraction, will not create any void in the body.
- As there is no need of finding a suitable donor, lot of time is being saved and the patient can immediately undergo treatment for the better outcome.
- For instances, many of the autologous stem cells therapies can be performed on an outpatient basis, without any application of general anesthesia.
Ankylosing Spondylitis: Watch out For Some Warning Indications
Don’t ignore your consistent, yet severe back pain as a common medical condition that almost everyone is suffering with! As apparently, according to the National Institute of Neurological Disorders, and Spastics Society of India, back pain can sometimes be an indication of more severe conditions, identified to be as the Ankylosing Spondylitis.
Ankylosing spondylitis is regarded as the progressive form of arthritis, mainly triggered in the spine but may even progressively risk hips, knees and shoulder joints, depending upon the severity of the issue. Back pain, being a more common issue is often vindicated with other milder forms; due to which, urban population is being reported to spend more than 50 billion $ in curing the lower back pain.
The research is mainly come up with the clarification that ankylosing spondylitis is an inflammatory arthritic condition of the spine, associated with vertebral fusion leading to immobility, decreased functionality and abnormal bone growth. Although, it is a kind of ailment, with which mainly older people are affected, some of the first sign of symptoms can as well appear in their early 20s. Conventionally, only steroidal medicines with anti-inflammatory properties were being offered to patients, with no possible curative measures. Moreover, long term exposure to hormonal supplements has been reported to aggravate other serious conditions like functional failures of important organs, such as liver, kidneys, etc.
However, recent medical advancements have suggested application of stem cells therapy to be a better and indeed more effective option, against offering better regeneration of deformed tissues. Thus, it would always be advisable that one has to be aware of the symptoms and what are they pointing towards at; which may lead towards increased accessibility for the better treatment.
If, in case one is suffering with some of the below mentioned symptoms then it could be ankylosing spondylitis, which needs urgent medical attention.
Unusual Back pain in the lower body
For almost every spinal cord ailment; back pain with simultaneous stiffness is the cardinal issue. Although, the pattern and the nature of these symptoms can be variable, depending upon the condition as well as severity of the ailment. In case of ankylosing, a person with symptomatic initialization, generally experiences shooting pain, starting at the lower back region towards his buttocks. The pain episodes are often gradual, spreading over few weeks to even month. Being an inflammatory disorder, pain as well as stiffness is often noted to increase in both the extremes, as in, due to over resting as well as due to exercise.
Unexplained pain in the neck, chest, heels and joints
Some people often have complained about extreme, unexplained pain in the heels, wrists, ankles, etc. A constant irritating pain may often reduce the functional capability of a person, leading him to completely immobile state. Sudden chest tightness, strapped-in feeling, tender ribs, difficulty in breathing can be linked with the existence of ankylosing spondylitis, which can aggravate progressively.
Eye Issues
Iritis, is often noted as one of the primary symptoms of degenerative spinal conditions, like AS. It is generally being referred as the spinal inflammation, associated with pain around eyes, headaches, light sensitivity, redness, change in pupil size, blurred or cloudy vision without any solid reasons, etc. If a person is experiencing one of these, along with his back issues, he has to get it checked for ankylosing, ASAP.
Frequent Fatigue & Mood swings
Progressively, since the pain and the stiffness episodes get flared up with more frequency, the continuous irritating pain can drag a person in more depression, functional inability and unexplained fatigue. Many of the reported cases have as well noted anemia as the primary issue, leading toward mood swings and fatigue.
Bowel and Bladder Problems
Prolonged state of diarrhea and passage of blood stools for more than 2 weeks continuously, is a serious indication of degenerative disc disorders, like AS and hence needs to be taken to an expert notification immediately for faster diagnosis. Bladder as well as bowel disorders, have been referred to as initial symptomatic indications of Ankylosing Spondylitis.
Thus, early investigation of progressive degenerative spinal conditions, like AS could lead to the in-timely prognosis; for which alternative regeneration of tissue can be achieved with the application of latest stem cells technology for better functional attributes and delaying the progressive degeneration.
Advancells
Ankylosing spondylitis is regarded as the progressive form of arthritis, mainly triggered in the spine but may even progressively risk hips, knees and shoulder joints, depending upon the severity of the issue. Back pain, being a more common issue is often vindicated with other milder forms; due to which, urban population is being reported to spend more than 50 billion $ in curing the lower back pain.
The research is mainly come up with the clarification that ankylosing spondylitis is an inflammatory arthritic condition of the spine, associated with vertebral fusion leading to immobility, decreased functionality and abnormal bone growth. Although, it is a kind of ailment, with which mainly older people are affected, some of the first sign of symptoms can as well appear in their early 20s. Conventionally, only steroidal medicines with anti-inflammatory properties were being offered to patients, with no possible curative measures. Moreover, long term exposure to hormonal supplements has been reported to aggravate other serious conditions like functional failures of important organs, such as liver, kidneys, etc.
However, recent medical advancements have suggested application of stem cells therapy to be a better and indeed more effective option, against offering better regeneration of deformed tissues. Thus, it would always be advisable that one has to be aware of the symptoms and what are they pointing towards at; which may lead towards increased accessibility for the better treatment.
If, in case one is suffering with some of the below mentioned symptoms then it could be ankylosing spondylitis, which needs urgent medical attention.
Unusual Back pain in the lower body
For almost every spinal cord ailment; back pain with simultaneous stiffness is the cardinal issue. Although, the pattern and the nature of these symptoms can be variable, depending upon the condition as well as severity of the ailment. In case of ankylosing, a person with symptomatic initialization, generally experiences shooting pain, starting at the lower back region towards his buttocks. The pain episodes are often gradual, spreading over few weeks to even month. Being an inflammatory disorder, pain as well as stiffness is often noted to increase in both the extremes, as in, due to over resting as well as due to exercise.
Unexplained pain in the neck, chest, heels and joints
Some people often have complained about extreme, unexplained pain in the heels, wrists, ankles, etc. A constant irritating pain may often reduce the functional capability of a person, leading him to completely immobile state. Sudden chest tightness, strapped-in feeling, tender ribs, difficulty in breathing can be linked with the existence of ankylosing spondylitis, which can aggravate progressively.
Eye Issues
Iritis, is often noted as one of the primary symptoms of degenerative spinal conditions, like AS. It is generally being referred as the spinal inflammation, associated with pain around eyes, headaches, light sensitivity, redness, change in pupil size, blurred or cloudy vision without any solid reasons, etc. If a person is experiencing one of these, along with his back issues, he has to get it checked for ankylosing, ASAP.
Frequent Fatigue & Mood swings
Progressively, since the pain and the stiffness episodes get flared up with more frequency, the continuous irritating pain can drag a person in more depression, functional inability and unexplained fatigue. Many of the reported cases have as well noted anemia as the primary issue, leading toward mood swings and fatigue.
Bowel and Bladder Problems
Prolonged state of diarrhea and passage of blood stools for more than 2 weeks continuously, is a serious indication of degenerative disc disorders, like AS and hence needs to be taken to an expert notification immediately for faster diagnosis. Bladder as well as bowel disorders, have been referred to as initial symptomatic indications of Ankylosing Spondylitis.
Thus, early investigation of progressive degenerative spinal conditions, like AS could lead to the in-timely prognosis; for which alternative regeneration of tissue can be achieved with the application of latest stem cells technology for better functional attributes and delaying the progressive degeneration.
Advancells
Quit Smoking Diet: Fight against Cravings
Many times, it comes into picture, when you would be reading about the possible cure for any chronic life threatening disease, such as cancer or neurodegenerative disorders. One should understand that the word can initiate number of responses, which can be credited as per the By now, everyone might have heard or at least read about the buzzword, ‘stem cell therapy’. situation as well as need. For instance, for vulnerable patients, who are not able to find out any definite cure through conventional medicine, stem cells therapy can be a hope; whereas for scientists, who are struggling hard to unlock the master key to cure, it is a sense of responsibility and a great deal of excitement about the promising future of stem cells therapy! Contrary to which, for medico-legal experts, patient’s long term safety and an ethical spirit of justice would be the priority. Thus, in order to have a better understanding of hopes vis-à-vis reality, we should certainly consider following points.
Laboratory findings associated with promising and essential therapeutic potential of stem cells! A Reality
The concept of repairing or regenerating internal faulty mechanisms was never new. Some animals and lizards are known as the masterminds of regeneration; remember those school time lessons? A salamander can grow his body parts again and again even after their amputation. Accordingly, we humans as well have the power of renewal, restoration as well as growth in order to be resilient to normal wear and tear of the body. With the latest research and technological up gradation this power of regeneration has now converted into a reality; through therapeutic application of stem cells.
Stem cells have been detected as early as eight celled stage of the embryo; undergoing multiple cell divisions to form an entire human being in mother’s womb. These cells have thus been named as the smart, naive cells present in the niche of every mature organ throughout their development; hence, these cells indeed are the building blocks of our body with the ability to stem up into cells of multiple origins. This can be the key towards successful cure of many degenerative conditions, associated with cellular loss.
Patients are really very excited to read and know more about stem cells therapies and how they can be beneficial! A Hope
Many people have been suffering from deadly, disabling conditions such as spinal cord injuries, neurodegenerative disorders, etc. Their lives are riddled with problems and are dependent on others for even bit of their happiness. For them, the breakthrough of stem cells therapy can definitely be the ray of hope; as even if they gain bit of independence, like being able to speak or show, a sense of touch towards their loved one or a control over their bowel as well as bladder- is a major advancement. Stem cells therapy involves their isolation, enrichment in a controlled environment and infusion back in the body; to promote regeneration of lost cells and functional restoration of an organ.
In reality, thus stem cells therapies have certainly proven to be life savers with many hundreds of legitimate clinical studies that are supporting the efficacy of stem cells in variety of degenerative conditions. But in any case, the bridge that connects the miraculous healing properties of stem cells and their routine approved use is long as well as arduous. Thus, it is in general a priority, whether to go ahead with stem cells therapy as safer alternative after trying everything else or to wait for the approval of prescriptive legislation, limiting the translation of scientifically approved concepts into therapeutically useful services.
Degenerative Eye Disorders: Can stem cells bring the hope back?
In connection with the popular saying that if anything isn’t broken, don’t fix it up; degenerative retinal diseases do need immediate medical attention, considering the severity of the issue. However, for many patients, who are experiencing a secondary condition rather than a pathological visual loss; have a better option with the help of stem cells therapies to delay disease progression. While the hope for the better treatment outcome and true breakthrough is still on the way!
Stem cells therapy can be offered as a restorative treatment approach, which has been acknowledged as the current most accessible treatment and a potential alternative to surgeries.With the help of modern medical interventions, it is possible to allow direct infusion of cells at the targeted locations in the back of the eye. It should be noted that human eye being a complex organ contains many different types of cells, like pigmented epithelial cells, ganglion cells as well as photoreceptor cells. Accordingly stem cells therapies can be employed to allow easy replacement for dying cell. Another reason that has forced researcher to acknowledge stem cells therapy as the better choice for degenerative eye disorder is their immune privileged nature, which minimizes the risk of tissue rejection; as the same has been so far a major concern for organ transplantation. Technology is now equipped with many personalized tools to measure internal ocular structure and their development through infusion of stem cells and hence the feasibility as well as the effectivity of stem cell application has been assessed through global research.
So far, a very crucial issue that is bothering general public is to choose from variety of different available sources of human stem cells. Although, the earlier emphasize were on application of embryonic stem cells, but significant ethical as well as safety concerns could have allowed researchers to explore for other adult sources. One of the many supported alternatives involve application of adult stem cells isolated from autologous tissue libraries, such as adipose tissues and bone marrow, which are observed to be the mixtures of growth modifiers as well as immune regulatory factors. These cells can be isolated from the said sources, enriched in the laboratory under controlled environment and can be infused back at the targeted site of injury. With the activation of alternative developmental pathways, these cells can regenerate lost cells of the eye, promote revascularization to improve blood circulation for better recovery and faster functional restoration.
Some of the common indications, which are identified to be treated with the help of stem cells therapy, are retinal diseases, that occur due to progressive neuronal loss along with loss of supportive essential cells. Thus, with the help of replacement possibilities offered by regenerative medicine; our future will include, fixing up those degenerative disorders that no longer had cure.
Possible Connection between Autism and Diabetes: Turn the Tide towards Prevention
In the past decades, there have been much speculations about the dire consequences associated with the adoption of on-the-go life style and their indirect attribution towards fueling the growing burden of chronic diseases, including autism. While upgrading their disease profile, it has been studied that diseases like diabetes and autism share a relatively high degree of connectivity in behavioral issues with similar physiological profile of metabolic and inflammatory dysregulations.
Conversely, while the prevalence of diabetes has crossed the alarming limit; a study has related it to another scary statistic of 1 in 88 children, confirmed to be autistic each year. A study further analyzed that the intrauterine exposure of fetus to the mother, with gestational diabetes can increase the risk of autism spectrum disorder in the child; apparently, children with autism are about thrice more likely to be affected with diabetes in the later stage of their life.
It would thus be a need of an hour to highlight a comparative relation between autism and diabetes and to identify effective therapeutic interventions for these young victims to turn the tide towards prevention.
In case, if anyone is not familiar with both these indications; autism is a wide spectrum of different types of neurological disorders in children, associated with behavioral issues, communication issues, and problems in their sensory activities. Whereas diabetes is a metabolic disorder, mainly associated with obesity.
Notably, above 45% of the children with ASD have above average intelligence, yet more than 25% of them are found to be completely nonverbal with critical social quotient. A data further confirms that about 32 percent of these children are overweight and 16 percent are categorized as obese; when compared with normal children, developing typically. Moreover, scientists have confirmed genetic risk factors for autism that have direct connection with weight issues. Another such study from Taiwan estimated that 1.6 % of autistic children were found to have developed diabetes, when compared to only 0.4% controls; while justifying these figures, they have attributed obesity in autistic individuals, as the major risk factor associated with diabetes.
As per the recent scientific revelations, women with gestational diabetes are known to be at a greater risk of having children with autism, who further are predisposed to diabetes, concerning the similarities between the genetic make-up of both the chronic diseases. Although, conventional medicine doesn’t have any clue so far, as to how effectively both these conditions can be managed; but the science of regenerative medicine has unlocked the mystery of finding potential cure at the cellular levels.
Stem cells are the basic cells, helping in building the cellular strength of humans; through their unlimited differentiation and multiplication potential. Number of investigative therapies have been put forth through decades of experimentation and clinical studies, and have confirmed the anti-inflammatory, regenerative potential of stem cells in curing neurodegenerative as well as autoimmune disorders, like autism and diabetes. These clinical studies have further concluded that stem cells can effectively alter behavioral outcomes, through reshaping brain patterns of autistic children; which can in turn be helpful in controlling their picky eating habits and weight.
Thus, these alternative novel therapies have so far proven to be very close to their clinical applications, to bear on disorders like autism and diabetes; which are without existing cure.
Conversely, while the prevalence of diabetes has crossed the alarming limit; a study has related it to another scary statistic of 1 in 88 children, confirmed to be autistic each year. A study further analyzed that the intrauterine exposure of fetus to the mother, with gestational diabetes can increase the risk of autism spectrum disorder in the child; apparently, children with autism are about thrice more likely to be affected with diabetes in the later stage of their life.
It would thus be a need of an hour to highlight a comparative relation between autism and diabetes and to identify effective therapeutic interventions for these young victims to turn the tide towards prevention.
In case, if anyone is not familiar with both these indications; autism is a wide spectrum of different types of neurological disorders in children, associated with behavioral issues, communication issues, and problems in their sensory activities. Whereas diabetes is a metabolic disorder, mainly associated with obesity.
Notably, above 45% of the children with ASD have above average intelligence, yet more than 25% of them are found to be completely nonverbal with critical social quotient. A data further confirms that about 32 percent of these children are overweight and 16 percent are categorized as obese; when compared with normal children, developing typically. Moreover, scientists have confirmed genetic risk factors for autism that have direct connection with weight issues. Another such study from Taiwan estimated that 1.6 % of autistic children were found to have developed diabetes, when compared to only 0.4% controls; while justifying these figures, they have attributed obesity in autistic individuals, as the major risk factor associated with diabetes.
As per the recent scientific revelations, women with gestational diabetes are known to be at a greater risk of having children with autism, who further are predisposed to diabetes, concerning the similarities between the genetic make-up of both the chronic diseases. Although, conventional medicine doesn’t have any clue so far, as to how effectively both these conditions can be managed; but the science of regenerative medicine has unlocked the mystery of finding potential cure at the cellular levels.
Stem cells are the basic cells, helping in building the cellular strength of humans; through their unlimited differentiation and multiplication potential. Number of investigative therapies have been put forth through decades of experimentation and clinical studies, and have confirmed the anti-inflammatory, regenerative potential of stem cells in curing neurodegenerative as well as autoimmune disorders, like autism and diabetes. These clinical studies have further concluded that stem cells can effectively alter behavioral outcomes, through reshaping brain patterns of autistic children; which can in turn be helpful in controlling their picky eating habits and weight.
Thus, these alternative novel therapies have so far proven to be very close to their clinical applications, to bear on disorders like autism and diabetes; which are without existing cure.
How to find a right stem cells clinic?
Thinking of fixing up your orthopedic issues? Or troubled with your chronic degenerative disorders and looking out for some alternative solutions? Apparently, many of you might have had number of questions, while choosing the right stem cells treatment for your condition; such as, is the stem cells therapy really effective? How to choose a stem cells clinic, which can offer the best possible? Etc.
Here’s what every one of you, should generally acknowledge, while choosing the best stem cells therapy provider.
Judge for the Experience
Proof of concept results, obtained from various clinical studies have evidently confirmed that experience is the most important parameter to be judged; for the better procedural outcome, to lower the chances of complications and to make smart choices, in case of adverse situations. In this regard, stem cells therapies are as well not an exception; and hence patients should enquire about their total experience in offering stem cell therapies with degenerative conditions and number of endorsements they have obtained so far. It is to be noted that in many of the medical procedures, the competency can be acquired somewhere after 40-60 numbers, whereas expertise can be gained, when the number will cross beyond several hundred.
Look for the data
While the alternative stem cells therapies are relatively new, with lot of ongoing research for the best investigational care; it is to be noted that the stem cell treatment provider should be well versed with the latest technological up gradation and should be aware of the current market trend at all times. Moreover, a therapy provider need to record, all the proceedings associated with the patient’s treatment plan; in the form of pain, function, preliminary testing’s done, previous medical history, family history, etc. The said data can be helpful in post procedural review to assess and grade clinical outcome of the patient, post stem cells therapy.
Source of isolation is very crucial
The stem cells are the naïve cells of body, with the ability to differentiate into different tissue specific cells. While developing human cellular makeup, these stem cells preserve themselves by creating a stem cells niche in each important organ, which can be retrieved back, in case of crisis. Some of these sources go totally underutilized, and hence can be exploited as abundant suppliers of stem cells like adipose tissue, bone marrow, etc. The technology has enabled the isolation of autologous stem cells from these well-known sources of the body. Being autologous in nature, these cells don’t pose any direct or indirect threat. Moreover, since stem cells are from your own sources, they know your body in a better way; hence, they can assist in a speedy recovery.
Processing technique is the critical aspect
As per the regulatory guidelines, stem cells are to be strictly processed under clean room, maintaining a controlled environment; to prevent further issue of contamination. Furthermore, a scientific expertise also has to be taken into consideration, because a technical variability can largely affect the extraction of viable stem cells. Since number of viable and specific stem cells isolation is the most critical step; it is advisable to ask for third party certificate of analysis, in order to know how many stem cells have been infused back.
Targeted Delivery to be emphasized
Many times, blind injections of stem cells are believed to have higher lost rates as compared to targeted delivery of the same. In this regard, a chosen clinic should have gained strong expertise in implementing targeted delivery of cells; in order to boost up the benefits.
Avoid Hype
Every medical procedure has success and failure rates, depending upon the medical as well as procedural backgrounds. It is the therapy provider’s responsibility to ensure that the good quality stem cells are delivered near site of injury, by minimizing bounce rates; however, he cannot guarantee 100% effective outcome in any circumstances, and if in case, he is then, he is not being truthful to you.
As a matter of fact, the effective treatment outcome is highly irregular factor, depending upon patient’s emotional as well as physical structure and severity of the disease, and if the gesture from the treatment provider is thoughtful and well analyzed regarding the recovery; then probably you have been on the right place.
Here’s what every one of you, should generally acknowledge, while choosing the best stem cells therapy provider.
Judge for the Experience
Proof of concept results, obtained from various clinical studies have evidently confirmed that experience is the most important parameter to be judged; for the better procedural outcome, to lower the chances of complications and to make smart choices, in case of adverse situations. In this regard, stem cells therapies are as well not an exception; and hence patients should enquire about their total experience in offering stem cell therapies with degenerative conditions and number of endorsements they have obtained so far. It is to be noted that in many of the medical procedures, the competency can be acquired somewhere after 40-60 numbers, whereas expertise can be gained, when the number will cross beyond several hundred.
Look for the data
While the alternative stem cells therapies are relatively new, with lot of ongoing research for the best investigational care; it is to be noted that the stem cell treatment provider should be well versed with the latest technological up gradation and should be aware of the current market trend at all times. Moreover, a therapy provider need to record, all the proceedings associated with the patient’s treatment plan; in the form of pain, function, preliminary testing’s done, previous medical history, family history, etc. The said data can be helpful in post procedural review to assess and grade clinical outcome of the patient, post stem cells therapy.
Source of isolation is very crucial
The stem cells are the naïve cells of body, with the ability to differentiate into different tissue specific cells. While developing human cellular makeup, these stem cells preserve themselves by creating a stem cells niche in each important organ, which can be retrieved back, in case of crisis. Some of these sources go totally underutilized, and hence can be exploited as abundant suppliers of stem cells like adipose tissue, bone marrow, etc. The technology has enabled the isolation of autologous stem cells from these well-known sources of the body. Being autologous in nature, these cells don’t pose any direct or indirect threat. Moreover, since stem cells are from your own sources, they know your body in a better way; hence, they can assist in a speedy recovery.
Processing technique is the critical aspect
As per the regulatory guidelines, stem cells are to be strictly processed under clean room, maintaining a controlled environment; to prevent further issue of contamination. Furthermore, a scientific expertise also has to be taken into consideration, because a technical variability can largely affect the extraction of viable stem cells. Since number of viable and specific stem cells isolation is the most critical step; it is advisable to ask for third party certificate of analysis, in order to know how many stem cells have been infused back.
Targeted Delivery to be emphasized
Many times, blind injections of stem cells are believed to have higher lost rates as compared to targeted delivery of the same. In this regard, a chosen clinic should have gained strong expertise in implementing targeted delivery of cells; in order to boost up the benefits.
Avoid Hype
Every medical procedure has success and failure rates, depending upon the medical as well as procedural backgrounds. It is the therapy provider’s responsibility to ensure that the good quality stem cells are delivered near site of injury, by minimizing bounce rates; however, he cannot guarantee 100% effective outcome in any circumstances, and if in case, he is then, he is not being truthful to you.
As a matter of fact, the effective treatment outcome is highly irregular factor, depending upon patient’s emotional as well as physical structure and severity of the disease, and if the gesture from the treatment provider is thoughtful and well analyzed regarding the recovery; then probably you have been on the right place.
Alzheimer Treatment by injecting stem cells: A Breakthrough or A quackery
Multiple types of brain disorders, including developmental disorders, psychological problems and neurodegenerative disorders have stumped both scientific as well medical communities, since years; in terms of human sufferings, management and socioeconomic burden. While a recent survey by WHO in order to underline, disability adjusted life years suggest brain disorders, as a leading cause of global disease burden with a very high corresponding cost. Thus, out of multiple degenerative and crippling diseases, neurodegenerative disorders are undoubtedly very destructive; affecting lives of more than few billion-people living globally.
Alzheimer is one such kind of neurodegenerative disorder, affecting more than 5 million people in developed countries; a brutal degenerative condition directly affecting person’s memory and judgmental ability. Instead of being front line attackers; the disease is associated with a direct attack on the central nervous system with a progressive functional and structural damage.
Clinicians, scientists and other researchers have been buzzing around the decades to find a potential cure for the disease that will work at the cellular level. Albeit, it is very true that innovation can be driven more powerfully by the passion; the passion to find a cure for degenerative diseases like Alzheimer. In this regard, stem cells and their clinical capacity have definitely challenged many long-held beliefs about the biology of human development.
A healthy brain manages to wash away potential toxins in the form of metabolic waste through the passage of a cerebrospinal fluid; which are being stored in Alzheimer Brain as plaque forming proteins that halt personal communication. While the leading culprit in the faulty functional aspects has been identified as a choroid plexus; a tissue in the brain that produces cerebrospinal fluid, repairing choroid plexus epithelial cells has been scientifically pinpointed as the only solution. In this regard, stem cells have been identified as the lead players, due to their regenerative potential.
Stem cells are the naïve cells of human body, with the ability to differentiate into multiple tissue specific cells; when coaxed through definitive signaling approach. This tremendous capacity of stem cells has been noted as the cure for generating large number of choroid plexus epithelial cells that have been lost or damaged due to environmental as well as genetic manifestations.
As hypothesized, number of clinical as well as laboratory studies have confirmed that stem cells could associate with the complete cure for Alzheimer in three different ways:
Thus the world was so far waiting for the breakthrough to treat Alzheimer’s, but with the current stem cells inventions, it has certainly found a huge turn around point to probe a brain for a living.
www.advancells.com
Alzheimer is one such kind of neurodegenerative disorder, affecting more than 5 million people in developed countries; a brutal degenerative condition directly affecting person’s memory and judgmental ability. Instead of being front line attackers; the disease is associated with a direct attack on the central nervous system with a progressive functional and structural damage.
Clinicians, scientists and other researchers have been buzzing around the decades to find a potential cure for the disease that will work at the cellular level. Albeit, it is very true that innovation can be driven more powerfully by the passion; the passion to find a cure for degenerative diseases like Alzheimer. In this regard, stem cells and their clinical capacity have definitely challenged many long-held beliefs about the biology of human development.
A healthy brain manages to wash away potential toxins in the form of metabolic waste through the passage of a cerebrospinal fluid; which are being stored in Alzheimer Brain as plaque forming proteins that halt personal communication. While the leading culprit in the faulty functional aspects has been identified as a choroid plexus; a tissue in the brain that produces cerebrospinal fluid, repairing choroid plexus epithelial cells has been scientifically pinpointed as the only solution. In this regard, stem cells have been identified as the lead players, due to their regenerative potential.
Stem cells are the naïve cells of human body, with the ability to differentiate into multiple tissue specific cells; when coaxed through definitive signaling approach. This tremendous capacity of stem cells has been noted as the cure for generating large number of choroid plexus epithelial cells that have been lost or damaged due to environmental as well as genetic manifestations.
As hypothesized, number of clinical as well as laboratory studies have confirmed that stem cells could associate with the complete cure for Alzheimer in three different ways:
- They can flush out plaque causing proteins from the brain, which are hampering neuronal communication through their powerful immunoregulation.
- Their strong paracrine strength can support quick transportation of choroid plexus epithelial cells to the brain and spinal cord for functional improvements
- Stem cells can prevent further neuronal damage through the creation of niche for various growth factors as well as memory immune cells.
Thus the world was so far waiting for the breakthrough to treat Alzheimer’s, but with the current stem cells inventions, it has certainly found a huge turn around point to probe a brain for a living.
www.advancells.com
Living with Spinal Cord Injuries: Can Stem Cells be the Answer!
Spinal cord injury is one of the progressively degenerating, crippling disorders attributing towards the dislocation of bones and vertebrae; which is a general resultant of trauma and/or injury.
The accidental injury generally damages connecting nerves internally; in order to halt the back and forth communication between brain and rest of the body parts. This communication gap is the primary cause of partial or complete loss of movement, paralysis as well as numbness. Apparently, many times it has also been evident that spinal cord may get affected not because of the injury but because of different types of nerve infection; which if ignored for a longer time, may allow unusual bleeding in between the spaces around the spinal cord. Some of the common forms of these notable infections are spinal steno sis, spine bifida, etc.
Emergency Care
A person with a potential threat to severe spinal cord damage should be hospitalized for an intensive care unit immediately. Stabilization of blood pressure, lung function and prevention of further damage to the spinal cord; should be emphasized with immediate effect. Other injuries are as well to be looked at; for an accidental damage.
Experts may prescribe some routine tests, in order to detect the extent of injuries. These tests can be
Classification of SCI is generally based on the extent of pain and loss of movement, associated with the damage. Moreover, when the damage is associated with neuronal loss, nerve locations and number of nerves that have been damaged can as well be referred to classify spinal cord injury.
Alternative Therapeutics
Through conventionally demonstrated medicines, it is generally impossible to completely cure spinal cord damage or paralytic aftereffects of injury. In fact, the anti-inflammatory medicines that have been prescribed conventionally can affect other vital organs of the body, due to continuous hormonal modifications. Although with the advent of stem cells through the science of regenerative medicines has proven to be very helpful in offering definite cure for SCI and other orthopedic related illnesses. The potential ability of these stem cells to be differentiated into neurons has been well studied and confirmed through different scientific literature and the same hypothesis can be applied to treat and restore back the functional attributes of damaged spinal cord.
Thus, stem cells and their regenerative powers can potentially work to solve the internal mysteries of spinal cord injury; but the extent of recovery and therapeutic outcome are still the challenges that are being faced by the medical fraternities.
The accidental injury generally damages connecting nerves internally; in order to halt the back and forth communication between brain and rest of the body parts. This communication gap is the primary cause of partial or complete loss of movement, paralysis as well as numbness. Apparently, many times it has also been evident that spinal cord may get affected not because of the injury but because of different types of nerve infection; which if ignored for a longer time, may allow unusual bleeding in between the spaces around the spinal cord. Some of the common forms of these notable infections are spinal steno sis, spine bifida, etc.
Emergency Care
A person with a potential threat to severe spinal cord damage should be hospitalized for an intensive care unit immediately. Stabilization of blood pressure, lung function and prevention of further damage to the spinal cord; should be emphasized with immediate effect. Other injuries are as well to be looked at; for an accidental damage.
Experts may prescribe some routine tests, in order to detect the extent of injuries. These tests can be
- Ultrasound checks of important vital organs
- Spinal X ray for complete spinal cord monitoring
- MRI and CT Scan
- Bone Density Test
Classification of SCI is generally based on the extent of pain and loss of movement, associated with the damage. Moreover, when the damage is associated with neuronal loss, nerve locations and number of nerves that have been damaged can as well be referred to classify spinal cord injury.
- Spinal nerve damage in the neck can cause paralysis of upper body parts, like chest, arms and legs.
- Damage in the middle portion of the spinal cord can be associated with the paralysis of the lower limbs.
- More severe injuries can affect person’s ability to breathe as well as bowel and bladder control.
Alternative Therapeutics
Through conventionally demonstrated medicines, it is generally impossible to completely cure spinal cord damage or paralytic aftereffects of injury. In fact, the anti-inflammatory medicines that have been prescribed conventionally can affect other vital organs of the body, due to continuous hormonal modifications. Although with the advent of stem cells through the science of regenerative medicines has proven to be very helpful in offering definite cure for SCI and other orthopedic related illnesses. The potential ability of these stem cells to be differentiated into neurons has been well studied and confirmed through different scientific literature and the same hypothesis can be applied to treat and restore back the functional attributes of damaged spinal cord.
Thus, stem cells and their regenerative powers can potentially work to solve the internal mysteries of spinal cord injury; but the extent of recovery and therapeutic outcome are still the challenges that are being faced by the medical fraternities.
STEM CELL TREATMENT FOR NEUROLOGICAL DISORDERS
A great deal of excitement has been spread since past couple of years about the possibility of exploiting stem cells to treat a variety of neurological conditions such as Parkinson’s Disease, ALS and DMD etc. Although, it is very much understood that the excitement is too obvious for healthcare professionals as well as patients suffering from these incurable diseases, the translation of the technology into treatments require thorough understanding of stem cells, their behavior and how they can be used to help the mankind. This understanding is important for both desperate patients and enthusiastic doctors.
What are neurological disorders?
To realize the potential of stem cells, we are here discussing about; we need to know the basic mechanism of our brain. Our brain is like the central processing unit of our body! All the information regarding even the minute function our body performs is generated and controlled by our brain. In order to fulfill these requirements, it has different sections in it such as memory, cognitive functions, control, etc. The information is generated depending upon the body’s requirement and passed on in the form of a signal. These signals are the kind of a language our brain uses to pass on the information. The information is passed through the network of cells known as neurons of the brain to different organs via the spinal cord. The signals are coded in the brain and decoded by the particular organ to receive the message, same as the current software technology, what we used in our day to day life. Although the computer has only one organ, the monitor; whereas our body has many, such as heart, muscles, liver, etc. You can now understand the complexity of the mechanism the brain has to perform in order to keep us going! If any time, the functional capacity of any of these regulatory bodies is damaged, we can face a lot of trouble to perform our daily chores of functions. Most of the times, in any case of neurological disorder; it has been commonly observed that due to some genotypic or phenotypic challenges, neurons are severely hampered and are totally unable to pass on the information, for what they are required to! Like in ALS, neurons are severely damaged to pass on the information to muscles and hence muscles are non functional. Similarly, in Alzheimer, due to protein deposition, function of neurons in the memory section of the brain is affected and hence slowly and progressively the person loses his ability to memorize.
Thus, in case of all brain disorders, scientists have adopted a common approach to use stem cells to replace the damaged neurons, which have already functionally lost due to diseased conditions such as dopamine producing neurons in case of Parkinson’s disease.
What should we know about the stem cells?
Stem cells are the very basic cells of our body, which can be isolated from as early as eight celled stage of embryonic development. Since then they undergo differentiation at every stage to become a full term baby. They are present even in fully developed human being! The stem cells, which are present in small niches of an adult organ are known as the adult stem cells. These cells are non functional throughout the life of an individual and come into the picture only in case of emergency. The human body is made up of trillions of differentiated cells, performing functions in each organ. These differentiated cells have very limited life span and have to be replaced by new functional cells in order to take over its duties. However, in a diseased state, the loss of cells is far more than its production; practically not allowing an organ to perform the function it is made for. In such a situation, stem cells come forward to replenish by removing malfunction cells, and divide rapidly to rebuild the entire system with the fully functional new differentiated cells.
How can stem cells be used in neurological disorders?
Stem cells cannot be used for replacing dead or damaged neurons in the case of a variety of disorders, but might as well can be useful in various other ways, such as supporting the diseased cells to boost up and as well controlling or adjusting the microenvironment to speed up the process of central nervous system. Thus, many scientists are supporting the fact that the stem cells can be uniquely useful in diseased condition to replenish, rejuvenate and repair; may be not only by replacing new neurons but also by reducing inflammation.
The future of stem cell treatments in neurological disorders?
The fact today is that, the potential of stem cell treatment for a variety of diseases is well proven with the careful, thorough and feasible clinical trials taking place all over the world. Although a lot to be still achieved, a well established method backed by thorough scientific excellence and principles is needed to effectively utilize them in day to day clinical practice.
What are neurological disorders?
To realize the potential of stem cells, we are here discussing about; we need to know the basic mechanism of our brain. Our brain is like the central processing unit of our body! All the information regarding even the minute function our body performs is generated and controlled by our brain. In order to fulfill these requirements, it has different sections in it such as memory, cognitive functions, control, etc. The information is generated depending upon the body’s requirement and passed on in the form of a signal. These signals are the kind of a language our brain uses to pass on the information. The information is passed through the network of cells known as neurons of the brain to different organs via the spinal cord. The signals are coded in the brain and decoded by the particular organ to receive the message, same as the current software technology, what we used in our day to day life. Although the computer has only one organ, the monitor; whereas our body has many, such as heart, muscles, liver, etc. You can now understand the complexity of the mechanism the brain has to perform in order to keep us going! If any time, the functional capacity of any of these regulatory bodies is damaged, we can face a lot of trouble to perform our daily chores of functions. Most of the times, in any case of neurological disorder; it has been commonly observed that due to some genotypic or phenotypic challenges, neurons are severely hampered and are totally unable to pass on the information, for what they are required to! Like in ALS, neurons are severely damaged to pass on the information to muscles and hence muscles are non functional. Similarly, in Alzheimer, due to protein deposition, function of neurons in the memory section of the brain is affected and hence slowly and progressively the person loses his ability to memorize.
Thus, in case of all brain disorders, scientists have adopted a common approach to use stem cells to replace the damaged neurons, which have already functionally lost due to diseased conditions such as dopamine producing neurons in case of Parkinson’s disease.
What should we know about the stem cells?
Stem cells are the very basic cells of our body, which can be isolated from as early as eight celled stage of embryonic development. Since then they undergo differentiation at every stage to become a full term baby. They are present even in fully developed human being! The stem cells, which are present in small niches of an adult organ are known as the adult stem cells. These cells are non functional throughout the life of an individual and come into the picture only in case of emergency. The human body is made up of trillions of differentiated cells, performing functions in each organ. These differentiated cells have very limited life span and have to be replaced by new functional cells in order to take over its duties. However, in a diseased state, the loss of cells is far more than its production; practically not allowing an organ to perform the function it is made for. In such a situation, stem cells come forward to replenish by removing malfunction cells, and divide rapidly to rebuild the entire system with the fully functional new differentiated cells.
How can stem cells be used in neurological disorders?
Stem cells cannot be used for replacing dead or damaged neurons in the case of a variety of disorders, but might as well can be useful in various other ways, such as supporting the diseased cells to boost up and as well controlling or adjusting the microenvironment to speed up the process of central nervous system. Thus, many scientists are supporting the fact that the stem cells can be uniquely useful in diseased condition to replenish, rejuvenate and repair; may be not only by replacing new neurons but also by reducing inflammation.
The future of stem cell treatments in neurological disorders?
The fact today is that, the potential of stem cell treatment for a variety of diseases is well proven with the careful, thorough and feasible clinical trials taking place all over the world. Although a lot to be still achieved, a well established method backed by thorough scientific excellence and principles is needed to effectively utilize them in day to day clinical practice.
Muscular Weakness and ALS: The Perils of being your own doctor!
If you are really worried about your more or less frequent muscular twitching and wondering, what if it turned out to be a horrific muscular degenerative ailment, such as ALS; should understand that muscular twitching is rather a common problem, affecting many millions of people across the globe and can as well be associated with stress or anxiety. Contrary to which, ALS is a neurodegenerative condition, which can be diagnosed with one of the many symptoms, like muscular twitching and is comparatively a rare issue. However, is should as well be noted that a person, who is often experiencing muscular twitching without any solid reasons can be vulnerable to the deadly degenerative conditions like ALS.
Muscles are important functional tissues of human anatomy and are often neglected over other vital organs of the body, such as heart, brain, etc. As a matter of fact, majority of muscular twitching cases have found to be evident due to muscular weakness anxiety; wherein often a muscle or a group of muscles feel unusually weak, rubbery and odd. Some people as well notice this issue, when they feel unusual weakness, numbness in their muscles, along with shaky and/or tired tissues. Many of them might as well have complaints about extreme weakness in their hands, feet, legs, arms, back and facial muscles; up to an extent that they suspect some serious medical concerns like MS, ALS, etc.
Although, both ALS as well as muscular anxiety sound to be similar, which is related to the muscular weakness; there is a big difference between the two! It should be noted down that ALS twitches are general resultant of dying muscles, due to a major disconnection of passage of information, between muscles and the brain; moreover, it would be body’s secondary response taking place only after the death of the muscles. Thus, ALS twitches will often be associated with immobility of that particular muscles, which can be noticed before the onset of twitching. Studies have further suggested that ALS twitches may often start through hand and leg, while may usually migrate in the forward direction; progressively, continuously as well as relentlessly. Contrary to which, muscular anxiety twitches can be random, affecting any muscles or group of muscles of the body and can migrate in a random motion throughout the entire body. Thus, if it’s an ALS, you won’t experience a twitch in your finger for an instance and then a twitch in the back for the next second!
If you are still concerned, whether it is an ALS or a muscular weakness; you can offer help from an expert, who will definitely ask you to undergo EMG, which will always be positive, if it is an ALS. Apparently, twitches without weakness and with negative EMG are not ALS for sure.
Thus, bottom-line of the discussion is as simple as, muscular weakness is due to the stress or anxiety and often can be related with deadly neurodegenerative conditions, such as ALS; but if your twitches are common, without any extreme weakness, are only appearing for few moments and are randomly migrating without any positive indication through EMG, then you do not have ALS!
Advancells
Muscles are important functional tissues of human anatomy and are often neglected over other vital organs of the body, such as heart, brain, etc. As a matter of fact, majority of muscular twitching cases have found to be evident due to muscular weakness anxiety; wherein often a muscle or a group of muscles feel unusually weak, rubbery and odd. Some people as well notice this issue, when they feel unusual weakness, numbness in their muscles, along with shaky and/or tired tissues. Many of them might as well have complaints about extreme weakness in their hands, feet, legs, arms, back and facial muscles; up to an extent that they suspect some serious medical concerns like MS, ALS, etc.
Although, both ALS as well as muscular anxiety sound to be similar, which is related to the muscular weakness; there is a big difference between the two! It should be noted down that ALS twitches are general resultant of dying muscles, due to a major disconnection of passage of information, between muscles and the brain; moreover, it would be body’s secondary response taking place only after the death of the muscles. Thus, ALS twitches will often be associated with immobility of that particular muscles, which can be noticed before the onset of twitching. Studies have further suggested that ALS twitches may often start through hand and leg, while may usually migrate in the forward direction; progressively, continuously as well as relentlessly. Contrary to which, muscular anxiety twitches can be random, affecting any muscles or group of muscles of the body and can migrate in a random motion throughout the entire body. Thus, if it’s an ALS, you won’t experience a twitch in your finger for an instance and then a twitch in the back for the next second!
If you are still concerned, whether it is an ALS or a muscular weakness; you can offer help from an expert, who will definitely ask you to undergo EMG, which will always be positive, if it is an ALS. Apparently, twitches without weakness and with negative EMG are not ALS for sure.
Thus, bottom-line of the discussion is as simple as, muscular weakness is due to the stress or anxiety and often can be related with deadly neurodegenerative conditions, such as ALS; but if your twitches are common, without any extreme weakness, are only appearing for few moments and are randomly migrating without any positive indication through EMG, then you do not have ALS!
Advancells
How Does PRP help in Wound Healing
Over the years, different therapeutic alternatives have been developed for skin healing by scientists worldwide, due to its scientific, clinical as well as economic outcome. Wound healing is rather a complex process with its own unique dynamics. The healing is often associated with a process that involves complete wound sealing, along with the formation of a new skin matrix. Although, it should as well be noted that some acute as well as chronic versions of wounds can be difficult to heal, as a result of other co morbidities and opportunistic infections. As a matter of fact, even a better wound care regimen cannot always be leading towards a better wound healing.
In this regard, patients own platelet rich plasma has been well identified since more than two decades to be an advanced treatment that is highly effective for many chronic as well as acute wounds. PRP or platelet rich plasma is the enriched fraction of patient’s own blood, so much so that it is been enriched above the baseline values of normal platelets. Studies have indicated that this clear suspension holding red cells, white cells and platelets can effectively activate clotting mechanism, while releasing various different proteinaceous growth factors that are essential for rapid healing and closure. Hence, it is being exploited as the effective component in many periodontal, maxillofacial as well as orthopedic surgery; apart from being an active treatment ingredient for skin issues and ulcers.
Practically, a PRP session is being implemented in a very fast and relatively easy way; not investing more than an hour for the completion. 30 ml of blood will be withdrawn from one of your forearms and will be transferred into sterile tube, further preventing its clotting. The platelet rich fraction will be processed and enriched in a controlled environment that is clinically approved through reputed regulatory authorities. Prepared PRP serum will be infused back at the site of injury, in combination with stem cells to allow faster recovery.
Platelets basically help in offering structural support and building up of matrix to regenerate damaged organelles of the tissues. Their identified secretions, such as platelet derived growth factors, transforming growth factors, angiogenesis factors, vascular endothelial growth factors, etc. allow speedy epithelization and faster sealing of the area of chronic wound. The important storage organelles of platelets, such as dense and alpha granules will activate the immunoregulatory mechanisms to kick start rapid healing processes, through
Inflammation: In order to remove harmful stimuli of body’s own immune cells and offer further protection against damaged cells, irritants as well as pathogens.
Regeneration: New cells are being regenerated quickly, to restore functional attributes of damaged tissues.
Recreation: New vasculature is being recreated to allow rapid blood circulation for easy passage.
Moreover, the platelet enriched PRP can as well play an important role in offering host defense mechanism; around the site of exposed wound by eliciting different chemical signaling pathways to attract immunowarriors like macrophages, white blood cells and interleukins for the complete protection from infection.
Accordingly, various clinical studies have confirmed the feasibility, safety as well as efficacy of the said topical growth factor supplements as an effective adjuvant for offering complete wound care solution.
Advancells
In this regard, patients own platelet rich plasma has been well identified since more than two decades to be an advanced treatment that is highly effective for many chronic as well as acute wounds. PRP or platelet rich plasma is the enriched fraction of patient’s own blood, so much so that it is been enriched above the baseline values of normal platelets. Studies have indicated that this clear suspension holding red cells, white cells and platelets can effectively activate clotting mechanism, while releasing various different proteinaceous growth factors that are essential for rapid healing and closure. Hence, it is being exploited as the effective component in many periodontal, maxillofacial as well as orthopedic surgery; apart from being an active treatment ingredient for skin issues and ulcers.
Practically, a PRP session is being implemented in a very fast and relatively easy way; not investing more than an hour for the completion. 30 ml of blood will be withdrawn from one of your forearms and will be transferred into sterile tube, further preventing its clotting. The platelet rich fraction will be processed and enriched in a controlled environment that is clinically approved through reputed regulatory authorities. Prepared PRP serum will be infused back at the site of injury, in combination with stem cells to allow faster recovery.
Platelets basically help in offering structural support and building up of matrix to regenerate damaged organelles of the tissues. Their identified secretions, such as platelet derived growth factors, transforming growth factors, angiogenesis factors, vascular endothelial growth factors, etc. allow speedy epithelization and faster sealing of the area of chronic wound. The important storage organelles of platelets, such as dense and alpha granules will activate the immunoregulatory mechanisms to kick start rapid healing processes, through
Inflammation: In order to remove harmful stimuli of body’s own immune cells and offer further protection against damaged cells, irritants as well as pathogens.
Regeneration: New cells are being regenerated quickly, to restore functional attributes of damaged tissues.
Recreation: New vasculature is being recreated to allow rapid blood circulation for easy passage.
Moreover, the platelet enriched PRP can as well play an important role in offering host defense mechanism; around the site of exposed wound by eliciting different chemical signaling pathways to attract immunowarriors like macrophages, white blood cells and interleukins for the complete protection from infection.
Accordingly, various clinical studies have confirmed the feasibility, safety as well as efficacy of the said topical growth factor supplements as an effective adjuvant for offering complete wound care solution.
Advancells
Therapeutic Potential of stem cells in Orthopedics
Variety of musculoskeletal disorders and other orthopedic injuries are in existence, without any definitive therapeutic alternative. These myriad of disease conditions could potentially be benefitted from upcoming technologies, such as stem cells therapy over surgery. The ultimate goal of the science of regenerative medicine is to allow functional restoration of ailing tissues, by understanding complex intracellular dynamics. The purpose of the present write up is to offer working potential of stem cells and discuss therapeutic modalities in case of many orthopedic disorders.
As a matter of fact, increasing awareness has allowed more accessibility towards the use as well as misuse of stem cells; without understanding their scientific basics. It should be noted that our body is made up of billions of cells, which are working together to complete different assigned tasks for the functional capability of a tissue. Although, when tissues are damaged as a result of diseased condition, their reparative mechanism becomes inefficient to take care of the apparent cellular loss, due to damage and hence additional supplementation becomes a necessity. Even tissue specific stem cells that are present in the niche of the tissue become incompetent, to take care of the tremendous degeneration. In this regard, stem cells therapy can be a potential alternative through which body’s other underutilized abundant stem cell sources can be exploited for the isolation of large number of stem cells, which can be processed under controlled environment and infused back at the site of injury; in order to reinforce strength of tissue specific stem cells. This reinforcement will in turn be capable of strengthening body’s response against diseased condition through secretion of different immune regulatory cells, regenerating lost or damaged cells and accelerating the process of functional recovery in a better way.
Additional, technological aspect of providing patient’s own platelet rich plasma along with concentrated stem cells is to allow rapid secretion of variety of growth factors, enzyme inhibitors and immunoregulatory hormones to modulate the process of healing. This platelet rich plasma, when coupled with regenerative potential of stem cells isolated from patients own body tissues can speed up the process of healing in a better way.
Myriad of diseases are being treated with stem cells therapy including musculoskeletal and orthopedic disorders. Studies have confirmed evidences of complete management of various orthopedic disorders, like:
The ultimate goal of regenerative medicines in the treatment of degenerative orthopedic disorders, is to reduce pain, undergo effective symptomatic management of the disease and halt the progression. Worldwide clinical studies that have been carried under the guidance of clinical and scientific professionals have indicated promising recovery benefits with great clinical outcome. Nevertheless, many independent investigators have studied feasibility, safety as well as accessibility of stem cells therapy, by effectively reducing pain and other symptomatic problem. So far noted success rates are found to be 70-90%; through effective pain relief, functional improvisation and steady disease management.
Thus, stem cells therapy is the current best viable option for the treatment of variety of degenerative disorders, which are based upon the sound biological principles.
Advancells
As a matter of fact, increasing awareness has allowed more accessibility towards the use as well as misuse of stem cells; without understanding their scientific basics. It should be noted that our body is made up of billions of cells, which are working together to complete different assigned tasks for the functional capability of a tissue. Although, when tissues are damaged as a result of diseased condition, their reparative mechanism becomes inefficient to take care of the apparent cellular loss, due to damage and hence additional supplementation becomes a necessity. Even tissue specific stem cells that are present in the niche of the tissue become incompetent, to take care of the tremendous degeneration. In this regard, stem cells therapy can be a potential alternative through which body’s other underutilized abundant stem cell sources can be exploited for the isolation of large number of stem cells, which can be processed under controlled environment and infused back at the site of injury; in order to reinforce strength of tissue specific stem cells. This reinforcement will in turn be capable of strengthening body’s response against diseased condition through secretion of different immune regulatory cells, regenerating lost or damaged cells and accelerating the process of functional recovery in a better way.
Additional, technological aspect of providing patient’s own platelet rich plasma along with concentrated stem cells is to allow rapid secretion of variety of growth factors, enzyme inhibitors and immunoregulatory hormones to modulate the process of healing. This platelet rich plasma, when coupled with regenerative potential of stem cells isolated from patients own body tissues can speed up the process of healing in a better way.
Myriad of diseases are being treated with stem cells therapy including musculoskeletal and orthopedic disorders. Studies have confirmed evidences of complete management of various orthopedic disorders, like:
- Acute and chronic osteoarthritis, degenerative arthritis of weight bearing joints
- Sports injuries, including ligament tear, tendonitis, etc.
- Spinal cord injuries like disc degeneration, facet joints, etc.
The ultimate goal of regenerative medicines in the treatment of degenerative orthopedic disorders, is to reduce pain, undergo effective symptomatic management of the disease and halt the progression. Worldwide clinical studies that have been carried under the guidance of clinical and scientific professionals have indicated promising recovery benefits with great clinical outcome. Nevertheless, many independent investigators have studied feasibility, safety as well as accessibility of stem cells therapy, by effectively reducing pain and other symptomatic problem. So far noted success rates are found to be 70-90%; through effective pain relief, functional improvisation and steady disease management.
Thus, stem cells therapy is the current best viable option for the treatment of variety of degenerative disorders, which are based upon the sound biological principles.
Advancells
Stem Cells Therapy: Don’t Operate but Regenerate!
With the recent advancements in the science of regenerative medicine, it would be a wise decision to think twice about trying stem cell therapy before stepping inside the operation theatre for your joint disorders. The advanced technology has eventually surprised many medical experts through astonishing clinical benefits that have been evident in variety of studies and mainstream trials. Moreover, the technology has as well proven to be avoiding further consequences of surgery, like general anesthesia, rehabilitation, recovery, etc.
Amongst lot of controversies, potential of stem cells and their reparative ability has been well acknowledged. Scientists and experts are progressing at a faster rate, to unleash the mysteries of body’s innate mechanism and methods to unlock the same. Thus, it is mandatory to spread awareness amongst the general public, regarding potential benefits of stem cells and how they can be applied to treat variety of diseases, before allowing yourself to be under the knife.
Ethically Approved
Human body is being functional through different important organs that are made up of billions of cells, working day and night. These cells are going through a continuous process of degeneration and regeneration; thus, new cells are being generated and old, warn out cells are being expelled out through the system, to continue uninterrupted functional attributes of organs. Stem cells have been identified as the birthing cells to regenerate new cells and are present in the niche of every organ to take care of their wear and tear.
The technology has enabled successful isolation of stem cells from these underutilized cells and hence is known to be ethically exempted.
Stem cells are body’s own warriors
Since stem cells are being isolated from your own body sources, they have been trusted as body’s own cells. They know your body in a better way and hence, autologous stem cells therapy has practically overruled the possibility of rejection or other opportunistic infection. This innovative approach of utilizing your own cells to regenerate the entire cellular system have strongly been admired by many, who have thought it to be an alternative over surgery.
Convenient and more accessible
As compared to other surgical procedures, stem cells therapy can be undergone through minimally invasive techniques for isolation of some of the abundant stem cells sources, such as fat and/or bone marrow, etc. Similarly, infusion of stem cells back at the site of injury has been standardized and formulated in the most advanced way; by generally ensuring maximum reach ability.
Potential of Regeneration
Research has confirmed regenerative ability of stem cells through variety of different clinical studies across the globe. Stem cells are in fact the mother cells of our body and are known to be differentiating into different types of tissue specific cells. During the human development inside mother’s womb, stem cells are the first cells to be isolated and are found to be converting into different cells at each stage of their maturity. This extraordinary ability of stem cells has been exploited as the current trend of treating variety of degenerative conditions, such as diabetes, brain diseases, etc; for which traditionally no cure was being established.
How can it be a better option over surgery?
Apparently, it is the truth that some adverse, chronic conditions may need surgery; for many ailments, wherein the cellular damage and damage to the organ is under control, can return to a normal life shortly after infusion of stem cells therapy. It has been estimated that once the patient undergoes autologous stem cells therapy as per its designed algorithm; he will be able to notice positive changes, in terms of normalization of mood, better stamina, improved digestion, improved disease management, etc. Moreover, a typical patient has been noted to return to his normal lifestyle, immediately next day to his stem cells therapy; whereas in case of surgery, he has to experience a longer recovery period, hospitalization and expensive rehabilitation process.
Stem cells therapy has thus been nominated as the better option to avoid risk of surgery, infection, blood clots and organ failure.
Advancells
Amongst lot of controversies, potential of stem cells and their reparative ability has been well acknowledged. Scientists and experts are progressing at a faster rate, to unleash the mysteries of body’s innate mechanism and methods to unlock the same. Thus, it is mandatory to spread awareness amongst the general public, regarding potential benefits of stem cells and how they can be applied to treat variety of diseases, before allowing yourself to be under the knife.
Ethically Approved
Human body is being functional through different important organs that are made up of billions of cells, working day and night. These cells are going through a continuous process of degeneration and regeneration; thus, new cells are being generated and old, warn out cells are being expelled out through the system, to continue uninterrupted functional attributes of organs. Stem cells have been identified as the birthing cells to regenerate new cells and are present in the niche of every organ to take care of their wear and tear.
The technology has enabled successful isolation of stem cells from these underutilized cells and hence is known to be ethically exempted.
Stem cells are body’s own warriors
Since stem cells are being isolated from your own body sources, they have been trusted as body’s own cells. They know your body in a better way and hence, autologous stem cells therapy has practically overruled the possibility of rejection or other opportunistic infection. This innovative approach of utilizing your own cells to regenerate the entire cellular system have strongly been admired by many, who have thought it to be an alternative over surgery.
Convenient and more accessible
As compared to other surgical procedures, stem cells therapy can be undergone through minimally invasive techniques for isolation of some of the abundant stem cells sources, such as fat and/or bone marrow, etc. Similarly, infusion of stem cells back at the site of injury has been standardized and formulated in the most advanced way; by generally ensuring maximum reach ability.
Potential of Regeneration
Research has confirmed regenerative ability of stem cells through variety of different clinical studies across the globe. Stem cells are in fact the mother cells of our body and are known to be differentiating into different types of tissue specific cells. During the human development inside mother’s womb, stem cells are the first cells to be isolated and are found to be converting into different cells at each stage of their maturity. This extraordinary ability of stem cells has been exploited as the current trend of treating variety of degenerative conditions, such as diabetes, brain diseases, etc; for which traditionally no cure was being established.
How can it be a better option over surgery?
Apparently, it is the truth that some adverse, chronic conditions may need surgery; for many ailments, wherein the cellular damage and damage to the organ is under control, can return to a normal life shortly after infusion of stem cells therapy. It has been estimated that once the patient undergoes autologous stem cells therapy as per its designed algorithm; he will be able to notice positive changes, in terms of normalization of mood, better stamina, improved digestion, improved disease management, etc. Moreover, a typical patient has been noted to return to his normal lifestyle, immediately next day to his stem cells therapy; whereas in case of surgery, he has to experience a longer recovery period, hospitalization and expensive rehabilitation process.
Stem cells therapy has thus been nominated as the better option to avoid risk of surgery, infection, blood clots and organ failure.
Advancells